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Research Article
Online Published: 12 Apr 2026
 


Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract

Abdou-rachidou Gaffo, Amivi Edéfia Akpalo, Kossivi Issa Saloufou, Corinne Routaboul, Kwashie Eklu-gadegbeku, Oudjaniyobi Simalou.


Abstract
Background: Natural molecules and plants extracts have been loaded into biomaterials hydrogels depending on the characteristics of the natural molecules.

Objective: We propose to explain PAA gel containing Adansonia digitata plant extract spontaneous dissolution and the contribution of CaCO3 or KOH to gelation.

Methods: Dissolved PAA3000 at 2.5% form a gel on which 2.5 g of extract was added. Either 10mL of CaCO3 (100 mM) or 100 uL of KOH (1M) were added till the gelation. TLC analysis were done on plant extract. Acidity was determined and IR-ATR analysis were performed on gel containing or not plant extract.

Results: TLC identified phytomolecules belong to flavonoids, tanins, coumarins and terpens groups. IR-ATR spectra showed that CaCO3 obtained hydrogel, displayed more intensive –OH alcohol thanks to polyphenols addition and confirmed by aromatic C=C bands. Vaterite vibrational band became more intensive. For KOH obtained hydrogels, any characteristic vibrational band of alcohol–OH, acidic –OH nor ester C-O was present. Phenolic –OH and C=C groups characteristic vibrational bands appeared. Acidity decreased with extract addition.

Conclusion: The ideal hydrogel (pH=6.3) was obtained with KOH. In perspectives, we will study medical applications in wound healing process.

Key words: Keywords: hydrogels, poly(acrylic acid), plant extract, gelation.


 
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How to Cite this Article
Pubmed Style

Gaffo A, Akpalo AE, Saloufou KI, Routaboul C, Eklu-gadegbeku K, Simalou O. Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equijost. Online First: 12 Apr, 2026.

Web Style

Gaffo A, Akpalo AE, Saloufou KI, Routaboul C, Eklu-gadegbeku K, Simalou O. Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. https://www.equijost.com/?mno=268896 [Access: July 01, 2026].

AMA (American Medical Association) Style

Gaffo A, Akpalo AE, Saloufou KI, Routaboul C, Eklu-gadegbeku K, Simalou O. Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equijost. Online First: 12 Apr, 2026.


Vancouver/ICMJE Style

Gaffo A, Akpalo AE, Saloufou KI, Routaboul C, Eklu-gadegbeku K, Simalou O. Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equijost, [cited July 01, 2026]; Online First: 12 Apr, 2026.


Harvard Style

Gaffo, A., Akpalo, . A. E., Saloufou, . K. I., Routaboul, . C., Eklu-gadegbeku, . K. & Simalou, . O. (0) Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equijost, Online First: 12 Apr, 2026.


Turabian Style

Gaffo, Abdou-rachidou, Amivi Edéfia Akpalo, Kossivi Issa Saloufou, Corinne Routaboul, Kwashie Eklu-gadegbeku, and Oudjaniyobi Simalou. 0. Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equity Journal of Science and Technology, Online First: 12 Apr, 2026.


Chicago Style

Gaffo, Abdou-rachidou, Amivi Edéfia Akpalo, Kossivi Issa Saloufou, Corinne Routaboul, Kwashie Eklu-gadegbeku, and Oudjaniyobi Simalou. "Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract." Equity Journal of Science and Technology Online First: 12 Apr, 2026.


MLA (The Modern Language Association) Style

Gaffo, Abdou-rachidou, Amivi Edéfia Akpalo, Kossivi Issa Saloufou, Corinne Routaboul, Kwashie Eklu-gadegbeku, and Oudjaniyobi Simalou. "Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract." Equity Journal of Science and Technology Online First: 12 Apr, 2026. Web. 01 Jul 2026


APA (American Psychological Association) Style

Gaffo, A., Akpalo, . A. E., Saloufou, . K. I., Routaboul, . C., Eklu-gadegbeku, . K. & Simalou, . O. (0) Formation of a new wound-healing hydrogel: biochemical interactions within a poly(acrylic acid) gel containing Adansonia digitata plant extract. Equity Journal of Science and Technology, Online First: 12 Apr, 2026.




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